The Genes to Cognition programme (G2C) established a framework for studying genes, brain and behaviour in order to link basic molecular research from genomes and experimental genetic organisms with human clinical studies of cognition. The G2C framework was developed around the current understanding of the molecular basis of learning & memory.This is geeky stuff for those not versed in neuroscience (and even those who are), but Grant makes the information accessible for non-neuroscientists.
The G2C programme collects and integrates data in the areas of psychiatry, human and mouse psychology, cellular neurophysiology and cell biology, proteomics and biochemistry, molecular biology, human and mouse genetics and genomics.
Early in his career Seth Grant helped develop the transgenic mice that Eric Kandel used in his studies of how memory works. Since then he has combined his skill in genetics with his work on isolating the proteins that form the functional components of the synapse. (The synapse is a key component in the nervous systems of all multi-cellular animals.) When we last talked back in BSP 51 I was particularly struck by how many of these proteins actually evolved with single celled life--long before the arrival of nervous systems.
Recently Grant's work has focused on the discovery that the vertebrate synapse is actually much more complex than the one present in invertebrates. For BSP 101 we got together to talk about two papers he and his collegues recently published in Nature Neuroscience. These papers explore how small changes in the synapse proteins effect learning in measurable ways.
Grant has a special gift for making complex ideas clear, which means that this interview can be enjoyed by all listeners, even those who are new to the Brain Science Podcast and neuroscience.
List of research papers by Seth Grant
- S.G.N. Grant, T. J. O'Dell, K. A. Karl, P. L. Stein, P. Soriano, and E. R. Kandel, "Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice." Science 258 (1992):1903-10.
- Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG, "Evolutionary expansion and anatomical specialization of synapse proteome complexity." Nature Neuroscience 11 (2008) 799-806.
- Nithianantharajah, J., Komiyama, N., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J. & Grant, S. G. N. “Synaptic scaffold evolution generated components of vertebrate cognitive complexity.” Nature Neuroscience 16 (2013) 16-24. doi:10.1038/nn.3276
- Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., O'Dell, T. J., Grant, S. G. N. & Komiyama, N. “Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior.” Nature Neuroscience 16 (2013) 25-32. doi:10.1038/nn.3277
See FREE transcript for more links and references
More episodes about brain evolution: BSP 47, BSP 48, and BSP 51
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