Friday, October 18, 2013

Brain Connections Underlying Accurate Introspection Revealed


Via Science Daily, a new study from UC Santa Barbara graduate student Benjamin Baird and colleagues has found evidence that "the ability to accurately reflect on perceptual experience" and "the ability to accurately reflect on memories" are not really correlated - the findings suggest that these may be two distinct introspective skills. The research has been published in the Journal of Neuroscience, behind a paywall (You may access this article (from the computer you are currently using) for 1 day for US $30.00), of course.

Science Daily offered a nice summary of the research (based on the press release from UC Santa Barbara), which is below - followed by the abstract from the original article.

Brain Connections Underlying Accurate Introspection Revealed

Oct. 16, 2013 — The human mind is not only capable of cognition and registering experiences but also of being introspectively aware of these processes. Until now, scientists have not known if such introspection was a single skill or dependent on the object of reflection. Also unclear was whether the brain housed a single system for reflecting on experience or required multiple systems to support different types of introspection.
A. This shows seed regions. B. This shows functional magnetic resonance imaging connectivity results. Top two panels: Metacognitive accuracy for perceptual decisions is associated with increased connectivity between the lateral anterior prefrontal cortex (aPFC) seed region and the right dorsal anterior cingulate cortex, bilateral putamen, right caudate and thalamus. Bottom two panels: Metacognitive accuracy for memory is associated with increased connectivity between the medial aPFC and right precuneus and the right intraparietal sulcus /inferior parietal lobule. (Credit: UCSB)

A new study by UC Santa Barbara graduate student Benjamin Baird and colleagues suggest that the ability to accurately reflect on perceptual experience and the ability to accurately reflect on memories were uncorrelated, suggesting that they are distinct introspective skills. The findings appear in the Journal of Neuroscience.

The researchers used classic perceptual decision and memory retrieval tasks in tandem with functional magnetic resonance imaging to determine connectivity to regions in the front tip of the brain, commonly referred to as the anterior prefrontal cortex. The study tested a person's ability to reflect on his or her perception and memory and then examined how individual variation in each of these capacities was linked to the functional connections of the medial and lateral parts of the anterior prefrontal cortex.

"Our results suggest that metacognitive or introspective ability may not be a single thing," Baird said. "We actually find a behavioral dissociation between the two metacognitive abilities across people, which suggests that you can be good at reflecting on your memory but poor at reflecting on your perception, or vice versa."

The newly published research adds to the literature describing the role of the medial and lateral areas of the anterior prefrontal cortex in metacognition and suggests that specific subdivisions of this area may support specific types of introspection. The findings of Baird's team demonstrate that the ability to accurately reflect on perception is associated with enhanced connectivity between the lateral region of the anterior prefrontal cortex and the anterior cingulate, a region involved in coding uncertainty and errors of performance.

In contrast, the ability to accurately reflect on memory is linked to enhanced connectivity between the medial anterior prefrontal cortex and two areas of the brain: the precuneus and the lateral parietal cortex, regions prior work has shown to be involved in coding information pertaining to memories.

The experiment assessed the metacognitive abilities of 60 participants at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, Germany, where Baird was a visiting researcher. The perceptual decision task consisted of visual displays with six circles of vertical alternating light and dark bars -- called Gabor gratings -- arranged around a focal point. Participants were asked to identify whether the first or second display featured one of the six areas with a slight tilt, not always an easy determination to make.

A classic in psychology literature, the memory retrieval task consisted of two parts. First, participants were shown a list of 145 words. They were then shown a second set of words and asked to distinguish those they had seen previously. After each stimulus in both the perceptual decision and the memory retrieval task, participants rated their confidence in the accuracy of their responses on a scale of 1 (low confidence) to 6 (high confidence).

"Part of the novelty of this study is that it is the first to examine how connections between different regions of the brain support metacognitive processes," Baird said. "Also, prior means of computing metacognitive accuracy have been shown to be confounded by all kinds of things, like how well you do the primary task or your inherent bias toward high or low confidence.

"Using these precise measures, we're now beginning to drill down and see how different types of introspection are actually housed in the real human brain," Baird concluded. "So it's pretty fascinating from that perspective."

Full Citation:
Baird, B, Smallwood, J, Gorgolewski, KJ, and Margulies, DS. (2013, Oct 16). Medial and Lateral Networks in Anterior Prefrontal Cortex Support Metacognitive Ability for Memory and Perception. The Journal of Neuroscience, 33(42): 16657-16665; doi: 10.1523/​JNEUROSCI.0786-13.2013
Benjamin Baird, Jonathan Smallwood, Krzysztof J. Gorgolewski, and Daniel S. Margulies
+ Author Affiliations


Convergent evidence indicates that frontopolar Brodmann area 10, and more generally the anterior prefrontal cortex (aPFC), supports the human capacity to monitor and reflect on cognition and experience. An important unanswered question, however, is whether aPFC is a homogeneous region that supports a general-purpose metacognitive ability or whether there could be regional specialization within aPFC with respect to specific types of metacognitive processes. Previous studies suggest that the lateral and medial subdivisions within aPFC may support metacognitive judgments of moment-to-moment perceptual processes and assessments of information from memory stored over longer time scales, respectively. Here we directly compared intraindividual variability in metacognitive capacity for perceptual decisions and memorial judgments and used resting-state functional connectivity (rs-fcMRI) to relate this variability to the connectivity of the medial and lateral regions of aPFC. We found a behavioral dissociation in metacognitive ability for perceptual and memorial judgments. Furthermore, functional connectivity analysis revealed distinct patterns of connectivity that correlated with individual differences in each domain. Metacognitive ability for perceptual decisions was associated with greater connectivity between lateral regions of aPFC and right dorsal anterior cingulate cortex, bilateral putamen, right caudate, and thalamus, whereas metacognitive ability for memory retrieval predicted greater connectivity between medial aPFC and the right central precuneus and intraparietal sulcus/inferior parietal lobule. Together, these results suggest that an individual's capacity for accurate introspection in the domains of perception and memory is related to the functional integrity of unique neural networks anchored in the medial and lateral regions of the aPFC.
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