Thursday, May 29, 2014

Transcriptomic Evidence for Immaturity of the Prefrontal Cortex in Patients with Schizophrenia

 

This new research from Molecular Brain shows, for the first time, that the gene expression patterns in the schizophrenic prefrontal cortex (PFC) resemble those in the juvenile PFC. This can possibly open new avenues for therapeutic interventions (not with drugs), including some of the Mindsight techniques developed by Dan Siegel that target the medial prefrontal cortex.

Full Citation:
Hagihara, H, Ohira, K, Takao, K and Miyakawa, T. (2014, May 29). Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia. Molecular Brain; 7:41. doi:10.1186/1756-6606-7-41

Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia

Hideo Hagihara, Koji Ohira, Keizo Takao and Tsuyoshi Miyakawa
Author Affiliations

Abstract (provisional)


Background

Schizophrenia, a severe psychiatric disorder, has a lifetime prevalence of 1%. The exact mechanisms underlying this disorder remain unknown, though theories abound. Recent studies suggest that particular cell types and biological processes in the schizophrenic cortex have a pseudo-immature status in which the molecular properties partially resemble those in the normal immature brain. However, genome-wide gene expression patterns in the brains of patients with schizophrenia and those of normal infants have not been directly compared. Here, we show that the gene expression patterns in the schizophrenic prefrontal cortex (PFC) resemble those in the juvenile PFC.

Results

We conducted a gene expression meta-analysis in which, using microarray data derived from different studies, altered expression patterns in the dorsolateral PFC (DLFC) of patients with schizophrenia with those in the DLFC of developing normal human brains, revealing a striking similarity. The results were replicated in a second DLFC data set and a medial PFC (MFC) data set. We also found that about half of the genes representing the transcriptomic immaturity of the schizophrenic PFC were developmentally regulated in fast-spiking interneurons, astrocytes, and oligodendrocytes. Furthermore, to test whether medications, which often confound the results of postmortem analyses, affect on the juvenile-like gene expressions in the schizophrenic PFC, we compared the gene expression patterns showing transcriptomic immaturity in the schizophrenic PFC with those in the PFC of rodents treated with antipsychotic drugs. The results showed no apparent similarities between the two conditions, suggesting that the juvenile-like gene expression patterns observed in the schizophrenic PFC could not be accounted for by medication effects. Moreover, the developing human PFC showed a gene expression pattern similar to that of the PFC of naive Schnurri-2 knockout mice, an animal model of schizophrenia with good face and construct validity. This result also supports the idea that the transcriptomic immaturity of the schizophrenic PFC is not due to medication effects.

Conclusions

Collectively, our results provide evidence that pseudo-immaturity of the PFC resembling juvenile PFC may be an endophenotype of schizophrenia.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.
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