Wolf's Rain - The City of Howls

Cool anime, and a cool story. Apparently this is a well-known series, but I have never followed anime.

Kiba, a wounded white wolf, goes to a city in search of the Lunar Flower that can open the door to paradise. There he meets Tsume, Hige, and Toboe, three other wolves using illusions to appear humans so they can live in relative safety in the city. All four soon find themselves the target of Quent Yaiden and his dog Blue, who seek to kill every remaining wolf in the world. Cheza, the Lunar Flower, awakens at Kiba's arrival, but she is stolen away by Darcia. The four wolves join together and leave the town. After a rough trip through a town that violently rejects all outsiders, the wolves are able to meet with Cheza, who sensed their presence below and jumped from Darcia's airship to float down to them.

Tags: Wolf's Rain, The City of Howls, episode one, animation, anime, Japan, animals, fiction