Thursday, February 02, 2012

Bookforum - Social contract theory for Occupiers

Another collection of links related to the #Occupy movement from the folks at Bookforum.

Wednesday, February 01, 2012

Kenneth Folk - Enlightenment for the Rest of Us


Enlightenment for the Rest of Us


This video is from last year's Buddhist Geeks conference - Kenneth Folk talks here about enlightenment (or its pursuit) by people who have lives and families. You can read the transcript at the site if you's prefer not to watch/listen.

Enlightenment for the Rest of Us


The following video took place at the Buddhist Geeks Conference in 2011, and was part of a series of live talks, each 20 minutes in length.

Talk Description: Drawing from Buddhism, neuroscience, and personal experience, Kenneth Folk explains that enlightenment is a natural aspect of human development that is available to everyone.




Open Culture - 30 Renowned Writers Speaking About God & Reason

This is very cool - and of course it comes from Open Culture, the curators of cool on the web. Some of the writers featured include Douglas Adams, Isaac Asimov, Iain Banks, Roddy Doyle, and no collection would be complete without Christopher Hitchens.

Enjoy - this is frequently fascinating.

As an added bonus, in the summary below, there are links to a two part video of 100 academics, mostly scientists, talking about their perspectives on God and reason.

30 Renowned Writers Speaking About God & Reason

January 30th, 2012



This past summer, Jonathan Pararajasingham, a neurosurgeon in London, created a montage of 100 renowned academics, mostly all scientists, talking about their thoughts on the existence of God. (Find it in two parts here and here.) Now’s he back with a new video, 30 Renowned Writers Speaking About God. It runs 25 minutes, and it offers as much a critique of orthodox religious belief as it does a literary tribute to humanism and rationalism. Isaac Asimov, Arthur C. Clarke, Salman Rushdie (who kindly tweeted us this weekend), Margaret Atwood, Philip Roth — they all make an appearance. The full list of writers appears below the jump.

And, before we close, let me say this. Whenever we post videos like these, we get the question. Why the occasional focus on atheism/rationalism/humanism? And the simple answer comes down to this: If you cover writers, academics and scientists, the thinking skews in that direction. Yes, there are exceptions, but they are in shorter supply. But if someone pulls them together and makes a montage, we’ll likely feature it too. H/T RichardDawkins.net

Note: As you may have noticed, we have been experiencing intermittent outages over the past couple of days. Our host, Dreamhost, has been stumbling more than we’d like. So we’re figuring out alternatives and hopefully making a move soon. Our apologies for the inconvenience!


1. Sir Arthur C. Clarke, Science Fiction Writer
2. Nadine Gordimer, Nobel Laureate in Literature
3. Professor Isaac Asimov, Author and Biochemist
4. Arthur Miller, Pulitzer Prize-Winning Playwright
5. Wole Soyinka, Nobel Laureate in Literature
6. Gore Vidal, Award-Winning Novelist and Political Activist
7. Douglas Adams, Best-Selling Science Fiction Writer
8. Professor Germaine Greer, Writer and Feminist
9. Iain Banks, Best-Selling Fiction Writer
10. José Saramago, Nobel Laureate in Literature
11. Sir Terry Pratchett, NYT Best-Selling Novelist
12. Ken Follett, NYT Best-Selling Author
13. Ian McEwan, Man Booker Prize-Winning Novelist
14. Andrew Motion, Poet Laureate (1999-2009)
15. Professor Martin Amis, Award-Winning Novelist
16. Michel Houellebecq, Goncourt Prize-Winning French Novelist
17. Philip Roth, Man Booker Prize-Winning Novelist
18. Margaret Atwood, Booker Prize-Winning Author and Poet
19. Sir Salman Rushdie, Booker Prize-Winning Novelist
20. Norman MacCaig, Renowned Scottish Poet
21. Phillip Pullman, Best-Selling British Author
22. Dr Matt Ridley, Award-Winning Science Writer
23. Harold Pinter, Nobel Laureate in Literature
24. Howard Brenton, Award-Winning English Playwright
25. Tariq Ali, Award-Winning Writer and Filmmaker
26. Theodore Dalrymple, English Writer and Psychiatrist
27. Roddy Doyle, Booker Prize-Winning Novelist
28. Redmond O’Hanlon FRSL, British Writer and Scholar
29. Diana Athill, Award-Winning Author and Literary Editor
30. Christopher Hitchens, Best-Selling Author, Award-Winning Columnist

Stuart Kauffman - On The Inadequacy Of The Empiricist Tradition In Western Philosophy


This post from Stuart Kauffman comes from NPR's 13.7 Cosmos and Culture blog. Here is a possible thesis: "Without being and doing, no knowing could have emerged in evolution. The empiricist tradition misses this central issue, thus is deeply inadequate."
I find myself beginning to realize that the philosophy that I studied, from Descartes to Hume to Kant to Russell to logical positivism and the early Wittgenstein, and perhaps the late Wittgenstein of the Investigations, is seriously inadequate.

It starts with Descartes who conceived of his task to be a lone mind who would doubt all that could be doubted to find that which could not be doubted about what that single mind can know about the world. The emphasis is on "knowing."

Then we come to Hume of the Scottish Enlightenment, essaying to understand "Human Understanding." How can we know the world? By sense impressions, welded together in "bundles," in which the "self," or "I," itself disappears as just a bundle of perceptions: roughly, "all I am aware of is a jumble of sequential awareness," I am aware of no 'I'."
 Kant seeks the conditions of knowing in the inner conditions of the mind, categories of perception such as space and time. He considers the phenomenal world we can know and behind it the noumenal world we can never know.

Russell brings us sense data such as "red here" and the tone, "A flat now," then sense data statements, "For Kauffman, 'red here' is true," and hopes that his recently developed predicate calculus working on sense data statements will allow philosophers to build a maximally reliable way of knowing the world, constructed out of sense data statements linked by logic, including quantifiers such as "there exists" and "for all."

To early Wittgenstein's famous "Tractatus": "The world is the collection of true facts" about that world.

On to logical positivism: "Only those statements (about the world) are meaningful which are empirically verifiable," which, ironically drove Western philosophy, yet whose founding statement just noted is not itself empirically verifiable.

The "empiricist tradition" sought and seeks to elucidate how we know the world.

What is wrong?

In the beginning, 5 billion years ago, no life existed on the forming planet. Either life started here or arrived from elsewhere. Let's assume the former. As a concrete working hypothesis let's take collectively autocatalytic sets of polymers like peptide sets, RNA sets, or DNA sets, all realized experimentally, in some bounding membrane like a liposome. For example Gonen Ashkenazi has a 9 peptide (small protein) collectively autocatalytic set reproducing happily in his Ben Gurion University lab.

So what?

So existing as a self reproducing system in a universe that is non-ergodic, (not repeating) above the level of atoms, where most complex things will never exist, is the first condition of life. "Knowing" is not yet a condition.

But that protocell typically lived in an environment with toxic and food molecules. By hook or crook, say by semipermiable membranes, the protocell "discriminated" poison from food and admitted only the latter, thanks to natural selection on evolving protocells.

We now have the rudiments of agency and knowing. The protocell evolved to do something, i.e., discriminate and admit food and block poison. This discrimination required rudimentary "knowing" and hence "semantics", without invoking consciousness.

What the empiricist tradition entirely misses is living existence and agency. Without the existence of the protocell, there is no evolutionary point in knowing. Without agency there is no use in knowing. Suppose, per contra, that the protocell could discriminate poison from food, but could not selectively block the first and admit the second. It would fail natural selection's harsh sieve.

Without being and doing, no knowing could have emerged in evolution. The empiricist tradition misses this central issue, thus is deeply inadequate.

In summary of this first point: Without being and agency, knowing is both pointless and would not arise in evolution.

Not only do we not know what will happen, we often do not even know what can happen.

But the empiricist tradition runs into a still deeper problem. In past posts I have discussed Darwinian preadaptations, where we cannot prestate their emergence in evolution. This has led my colleagues, senior mathematician, Giuseppe Longo, his post doctoral fellow, Mael Montevil, both of the Ecole Polytechnique, Paris, and myself to submit a paper also posted on ArXiv, entitled, "No entailing laws, but enablement in the evolution of the biosphere."

This article is radical. It claims that no law entails the evolution of the biosophere. The grounds for this include the fact that we cannot prestate the ever newly emerging relevant variables in evolution that selection reveals, therefore the very phase space of evolution changes in ways we cannot know beforehand, so we can write no laws of motion for the evolving biosphere, nor, lacking knowledge of the boundary conditions, could we integrate those laws of motion even were to to have them.

These deep issues mean that often not only do we not know what will happen, as when we flip a fair coin 10,000 times and do not know how many heads will come up, but here know all the possible outcomes, so can construct a probability measure. In evolution we do not even know what can emerge in the Adjacent Possible of the becoming of evolution, so can construct no probability measure for we do not know the sample space of all the possibilities, thus not only do we not know what will happen, we do not even know what can happen.

The empiricist tradition is ignorant of this profound limitation to knowledge "beforehand" as the biosphere "becomes."

Even pragmatism, which seeks to unify knowing and doing, falls prey to this last issue: We often do not even know what can happen. Pragmatism takes no account of this feature of our living world.

Hume famously argued that one cannot deduce "ought" from "is." This is the naturalistic fallacy. But Hume is thinking only of a knowing subject, firmly in the empiricist tradition started by Descartes. Hume ignores agency.

I wrote an entire book, Investigations, attempting to define agency. My try: "A molecular autonomous agent is a self-reproducing system able to do at least one work cycle."

A bacterium swimming up a glucose gradient for food is an agent, reproduces and the rotating flagella is just one of the work cycles the bacterium does. All living cells fulfill the above definition.

But once there is agency, ought enters the universe. If the bacterium is to successfully get food, it "ought" to e.g., swim up the sugar gradient. Without attributing consciousness, one cannot have "actings" without "doing them wisely or poorly," hence ought.

In short, the empiricist tradition, in ignoring agency, wishes to block us from "ought," when we cannot have doing without "ought." The root of the issue is "doing" versus merely "happening," a topic in a near future post.

We need to rethink many problems in philosophy to take account of the issues above.

Upaya Dharma Podcasts - Awakening to Buddha Nature - Whole Series


This is an interesting and informative series from Upaya Zen Center. There are 18 parts, so I am only sharing the first link - the rest of thinks are below.

John Dunne & Beate Stolte: 01-18-12: Awakening to Buddha Nature (Part 1)

Speakers: John Dunne & Beate Stolte
Recorded: Wednesday Jan 18, 2012

Series Description: The continuity between ordinary consciousness and the fully awake state of Buddhahood is called Tathagatagarbha or “Buddha Nature.” What is this “Buddha Nature”, and how can it be actualized in one’s everyday experience? Asking these and other questions, and using various modes of inquiry to do so, we will explore what is essential to the realization of Buddha Nature. We will consider what is already known about this Buddha principle in various traditions, the ways we know, as well as the emotional framework of that knowledge.

During the retreat John Dunne will teach Buddhist Philosophy and the Dharma in his brilliant and humorous way, which makes it easily accessible for western practitioners. This retreat is appropriate for beginners and long-time practitioners. Sensei Beate will lead morning and evening meditation and will give meditation instructions.

John Dunne is an associate professor in the Department of Religion at Emory University, where he is Co-Director of the Encyclopedia of Contemplative Practices and the Emory Collaborative for Contemplative Studies. He was educated at the Amherst College and Harvard University, where he received his Ph.D. from the Committee on the Study of Religion in 1999. 

His work focuses on various aspects of Buddhist philosophy and contemplative practice. In Foundations of Dharmakirti’s Philosophy (2004), he examines the most prominent Buddhist theories of perception, language, inference and justification. His current research includes an inquiry into the notion of “mindfulness” in both classical Buddhist and contemporary contexts, and he is also engaged in a study of Candrakirti’s “Prasannapada”, a major Buddhist philosophical work on the metaphysics of “emptiness” and “selflessness.” His recently published work includes an essay on neuroscience and meditation co-authored with Richard J. Davidson and Antoine Lutz. He frequently serves as a translator for Tibetan scholars, and as a consultant, he appears on the roster of several ongoing scientific studies of Buddhist contemplative practices.

Sensei Beate Genko Stolte is a Zen teacher and the first Dharma successor of Roshi Joan Halifax in the lineage of Taizan Maezumi Roshi. Born in Germany, she has practiced Zen for more than 20 years and was priest-ordained in the lineage of Shunryu Suzuki Roshi (“Zen Mind, Beginners Mind”). She has degrees in business administration and fiscal law. She has lived, practiced, and taught in Zen Buddhist communities in the United States, Switzerland and Germany and visited Japan for Zen Buddhist studies. As a co-founder of a German Buddhist Study Center, she served as president of the board for ten years as well as director.

To access the entire series, please click on the link below:

Awakening to Buddha Nature Series: All 18 Parts

Play

Awakening to Buddha Nature Series: All 18 Parts

Recorded: Sunday Jan 29, 2012

The 18 part series Awakening to Buddha Nature is now published. Also, please note that the Jan 18th dharma talk (episode # 561, titled: Faith and Reason) was an introduction to this series.

You can access the desired part of the series by clicking on its link below:

Awakening to Buddha Nature Series: Part 1
Awakening to Buddha Nature Series: Part 2
Awakening to Buddha Nature Series: Part 3
Awakening to Buddha Nature Series: Part 4
Awakening to Buddha Nature Series: Part 5
Awakening to Buddha Nature Series: Part 6
Awakening to Buddha Nature Series: Part 7
Awakening to Buddha Nature Series: Part 8
Awakening to Buddha Nature Series: Part 9
Awakening to Buddha Nature Series: Part 10
Awakening to Buddha Nature Series: Part 11
Awakening to Buddha Nature Series: Part 12
Awakening to Buddha Nature Series: Part 13
Awakening to Buddha Nature Series: Part 14a
Awakening to Buddha Nature Series: Part 14b
Awakening to Buddha Nature Series: Part 15
Awakening to Buddha Nature Series: Part 16
Awakening to Buddha Nature Series: Part 17
Awakening to Buddha Nature Series: Part 18

Tuesday, January 31, 2012

Salon - So what if America is the most religious nation?

In this article, Salon author Bernard Starr argues that while America may be the most religious nation in the developed world, that is hardly represented in how we treat our citizens. In all fairness, this is more an indictment of our government than our churches - at the local level the churches do a lot to help the weak and the poor, but the Federal Government does very little anymore in this realm, mostly as a result of Republican politics.

The real challenge is to balance being like Jesus in our caring for the weak and the poor with the fact the government is not always the best way to do this, especially when the federal budget is bloated and debt-ridden.

So what if America is the most religious nation?

if you compare creed and deed, the claim is hollow

 
America the religious
Polls consistently tell us that America is the most religious nation in the industrialized world. More that 90 percent of our population say they believe in God, and that they pray regularly. The figure may even be higher when adding the majority of Americans who claim to be atheists but pray, one-third of them often, according to a Baylor University survey.

A Rice University study of 275 scientists at 21 “elite” research universities in the United States found that while 61 percent declared themselves atheists or agnostics, 17 percent have attended church services. Whether genuine devotees, just hedging their bets or doing it for the children (as some say), there’s little doubt that America is a religious nation.

But does professing religious beliefs translate into acting in accord with religious principles? Isn’t behavior the true test? In his New Testament epistle, James expressed the Christian view that “faith without works is dead.” Similarly, Judaism calls for “mitzvahs” — good deeds. And Islam requires acts of charity. Poet Ralph Waldo Emerson offered this challenging formula for sincerity: “Go put your creed into your deed.”

How do creed and deed match up? The 2011 report card for religious America.

More people are slipping into poverty in the United States. The Associated Press recently reported that the U.S. poverty rate rose to a new record of 49.9 million — 16 percent of the U.S. population — based on a more comprehensive Census Bureau measure of poverty. That’s a leap over the 46.2 million previously reported, which was called the highest number in the 52 years the bureau has been publishing figures on poverty.

The number of working poor continues to increase. Today, nearly 1 out of every 3 families in the United States is considered to be “low income” According to the just released 2010-2011 policy brief of the ”Working Poor Families Project” the number of working poor in the United States is higher than ever before seen and “continues to increase at a staggering pace.”

Statistics from the Coalition for the Homeless reveal that 3.5 million Americans are homeless each year with 730,000 homeless on any given night. Of that number, 100,000 are homeless veterans. And children make up 23 percent of the homeless on any given night. Also, 770,000 homeless children are registered in public education systems.
Keep reading - the statistics are staggeringly bad.

Donna Orange - Beyond Instinct & Intellect: Modern Psychoanalysis

I posted this video a while back, but I just watched it again - Donna Orange has been one of the theorists most closely aligned with Robert Stolorow and his intersubjective systems theory of psychoanalysis (see Working Intersubjectively: Contextualism in Psychoanalytic Practice, with Stolorow and George Atwood).

A major aspect of the new model of psychoanalysis that Orange and Stolorow (and others) work with is the intersubjective relational elements of development and adult relationships, especially as it manifests in the therapeutic alliance. In this perspective, the therapist is no longer a blank slate onto whom the client projects transferences and "hidden drives," but rather, an integral part of the therapeutic dyad, a participant with the client in healing developmental wounds.




Beyond Instinct & Intellect: Modern Psychoanalysis from The New School on FORA.tv


Beyond Instinct & Intellect: Modern Psychoanalysis
George Hagman, author of Aesthetic Experience: Beauty, Creativity, Donna Orange, author of Emotional Understanding, and Thinking for Clinicians, debate the future of psychoanalysis.

They ask whether or not a cross-disciplinary approach is possible in approaching psychotherapy.

George Hagman

George Hagman is the author of Aesthetic Experience: Beauty, Creativity and the Search for the Ideal, and is faculty at National Psychological Association for Psychoanalysis. He has published numerous articles. He is the director of Clinical Outpatient Services, Southwest Connecticut Mental Health System.

Dr. Donna Orange

Donna Ornage is Faculty, Training, and Supervising Analyst at Institute for the Specialization of Relational Psychoanalytic Psychology in Rome, as well as faculty and supervising analyst at The Institute for the Study of Subjectivity in New York. She has co-authored two works, Worlds of Experience (2002), and Working Intersubjectively, as well as authored on her own, Emotional Understanding, and Thinking for Clinicians.

Musicians@Google: Joshua Bell & Jeremy Denk

Awesome - Joshua Bell is a fabulous musician. I first became aware of his talent through an experiment he participated in for the Washington Post.
Will one of the nation's greatest violinists be noticed in a D.C. Metro stop during rush hour? Joshua Bell experimented for Gene Weingarten's story in The Washington Post (Video by John W. Poole)



Here is the Google video.




Musicians@Google: Joshua Bell & Jeremy Denk
Musicians Joshua Bell and Jeremy Denk visit Google's New York, NY office to performed a few selections from their new album "French Impressions." After the performance, Bell and Denk chat with Google's Eileen Naughton about their collaboration.

On their new album "French Impressions," Grammy-award-winning violinist Joshua Bell and his longtime friend and recital partner, pianist Jeremy Denk offer a passionately nuanced interpretation of works by Saint-Saëns, Ravel and Franck. "French Impressions" boasts a number of milestones: it's Bell's first CD of sonatas since joining Sony Classical in 1996; it is Bell and Denk's first recital album together, and it's the first commercial recording made at the Musical Instrument Museum in Phoenix.

Joshua Bell has enchanted audiences worldwide with his breathtaking virtuosity and tone of rare beauty. His restless curiosity and multifaceted musical interests have taken him in exciting new directions which have earned him the rare title of "classical music superstar." Often referred to as the poet of the violin, Bell is the recipient of the Avery Fisher Prize and is the newly named Music Director of The Academy of St. Martin in the Fields. Bell first came to national attention at the age of 14 in a highly acclaimed orchestral debut with Riccardo Muti and the Philadelphia Orchestra. His Carnegie Hall debut and a recording contract further confirmed his presence in the music world. Today he is equally at home as a soloist, chamber musician, orchestra leader and composer who performs his own cadenzas to several of the major concerto repertoire.

American pianist Jeremy Denk has steadily built a reputation as one of today's most compelling and persuasive artists with an unusually broad repertoire. He has appeared as soloist with many major orchestras, including the Atlanta, Dallas, Houston, New World, St. Louis, and San Francisco Symphonies, the Philadelphia Orchestra, Orchestra of St. Luke's, Orpheus Chamber Orchestra, and London Philharmonia.

Monday, January 30, 2012

NPR - Can Ketamine Offer 'Almost Immediate' Relief From Depression?

The other day I posted some convincing arguments against the effectiveness of conventional SSRI antidepressants in treating depression. What that argument comes down to is the lack of evidence that depression is connected to low serotonin levels - what seems more likely is that raising serotonin levels essentially creates a "high" that masks the depression.

However, over the last several years there is increasing evidence that a drug never intended to treat mood disorders may be the most effective antidepressant ever developed. That drug is ketamine, and anesthetic - but it is also a popular (and illegal) club drug known as "Special K."

We have no idea how this drug really works, but it works far better than any current antidepressant developed specifically for that purpose. We suspect, at this point, that ketamine may alter - increase - the communication between neurons. This is far more rapid than the possible outcome from SSRI's, which depends on the creation of new neurons for any possible efficacy.

I've posted research supporting the use and efficacy of ketamine in the past, but there is a new article on NPR's site, Shots: NPR's Health Blog.
Ketamine has been used as an anesthetic for decades. It's also a widely popular but illegal club drug known as "Special K." When administered in low doses, patients report a rapid reduction in depression symptoms.
Huw Golledge/flickr

Ketamine has been used as an anesthetic for decades. It's also a widely popular but illegal club drug known as "Special K." When administered in low doses, patients report a rapid reduction in depression symptoms.

There's no quick fix for severe depression.

Although antidepressants like Prozac have been around since the 1970s, they usually take weeks to make a difference. And for up to 40 percent of patients, they simply don't work.

As a result, there are limited options when patients show up in an emergency room with suicidal depression.

The doctors and nurses at Ben Taub General Hospital in Houston say they see this problem every day.

You can get a sense of what they're up against by visiting the cavernous, bustling emergency center at Ben Taub, which is part of the massive Texas Medical Center. More than 100,000 patients a year get emergency care here, and about 5,000 of them need psychiatric evaluation.
 The hospital's 24-hour Psychiatric Emergency Center gets a steady stream of people with suicidal depression, says Charlzetta McMurray-Horton, who is in charge of mental health nursing.

Ben Taub General Hospital in Houston sees 100,000 emergency patients a year, 5,000 of whom need psychiatric evaluation.
Ben Taub General Hospital

Ben Taub General Hospital in Houston sees 100,000 emergency patients a year, 5,000 of whom need psychiatric evaluation.

"If the police bring them in, they're going to come through this door," McMurray-Horton says, pointing to one entrance. "If the ambulance brings them in, they're going to come through this door," she says, pointing to a different entrance.

And one of the challenges in treating these severely depressed patients is that there simply isn't any drug that provides quick relief, says Anu Matorin, medical director of the Psychiatric Emergency Center.

Matorin talks about one recent patient. The woman had suffered bouts of depression since college, Matorin says. But after she had a baby, it became severe. She stopped eating and sleeping. She began to think about suicide.

Finally, the woman made a desperate call to her mother, Matorin says.

"She was very emotional, very tearful, not making sense," Matorin says. "She says, 'I just can't take it anymore. I don't know how to feed the child.' The mother could hear the infant crying in the background."

The family called 911, and the woman arrived at the hospital with a police escort. Matorin says she evaluated the woman and put her on antidepressants.

Then came the hard part, Matorin says. She knew the drugs might help the woman eventually. But they weren't going to do anything about her suicidal thoughts during the next few critical days.

So Matorin did the only thing she could for her patient. She admitted her to the hospital's locked inpatient unit.

I ask to see the facility, so McMurray-Horton takes me there.

'Keep Them Safe, Keep Them Alive'

The unit can handle 20 patients, and its main room is warmer, softer and more colorful than you might expect. Think Holiday Inn, without any sharp objects or hard edges.

But there's no avoiding the fact that this is a place where safety is paramount and privacy isn't, says McMurray-Horton. Shatterproof plastic windows around the nurses' station provide unobstructed sightlines to pretty much everywhere.

"Patients don't want to be here," says McMurray-Horton, explaining that about three-quarters of them are in the unit because they have been deemed a threat to themselves or someone else.

So it's not surprising that our tour of the unit is interrupted by the loud protests of one enraged patient.

Units like this are necessary in part because drugs for depression don't work fast enough to help someone in the early days of a crisis, Matorin says.

And McMurray-Horton says staff members here have a simple goal for patients in crisis: "Keep them safe, keep them alive until they're in a different space."

Counseling can help, McMurray-Horton says. So can family. And she says most people in crisis just start to feel better after a few days in a place where staff make sure that "they stay in, and the world stays out."

That was certainly true of the depressed young mother that Matorin admitted. She got better and went home several days later.

But that woman probably could have skipped the hospital stay altogether if the drugs used to treat depression were as quick and effective as, say, painkillers, Matorin says.

If drugs were more effective, "I think it would transform psychiatric care and really eliminate some of the stigma and fear and concern about treatment," she says.

'A Completely Different Mechanism'

A growing number of scientists think it won't be long before psychiatric care is transformed.

And they are particularly excited about an experimental drug that is being tried in the NeuroPsychiatric Center next to Ben Taub hospital.

It's here that drug researchers are studying a drug that's unlike anything now used to treat depression. And they're giving it to patients who haven't done well on existing drugs.

One of these patients is Heather Merrill, who speaks to me in a small conference room that is part of the large and very busy outpatient clinic.

Merill is 41, with three kids and a nice house in the suburbs.

"I've suffered from depression for most of my adult life," she says. "It got to the point where I kind of felt like there wasn't going to be anything that was going to be able to help me."

At times her depression gets so bad that she can't take care of her family or even herself, she says.

And that's how she was feeling the day before, she says, when doctors placed an IV in her arm and began to administer a drug.

Because it was part of an experiment, there were two possibilities. The drug could have been just a sedative. Or it might have been something called ketamine.

Ketamine has been used for decades as an anesthetic. It also has become a wildly popular but illegal club drug known as "Special K."

Mental health researchers got interested in ketamine because of reports that it could make depression vanish almost instantly.

In contrast, drugs like Prozac take weeks or even months. And the frustrating thing is that depression medications really haven't changed much since Prozac arrived in the 1970s, says Sanjay Mathew from Baylor College of Medicine, who is in charge of the ketamine study at Ben Taub.

"Everything since then has been essentially incremental," he says. "There have been tweaks of existing molecules."

But ketamine represents much more than a tweak, Mathews says.

"It's a completely different mechanism," he says. "And the focus is on really rapidly helping someone get out of a depressive episode."

'No More Fogginess. No More Heaviness.'

Heather Merrill says she's pretty sure it was ketamine that flowed into her veins 24 hours earlier.

"It was almost immediate, the sense of calmness and relaxation," she says.

Some of the doctors think she might be right.

"Her demeanor has changed tremendously," says Dr. Asim Shah, who directs the mood disorder program at Ben Taub. "She looks like a happy person who is genuinely happy, whereas before the study, she looked very down, very withdrawn, sort of almost tearful."

But of course, nobody knows whether Merrill actually got ketamine. That information will be kept secret until the study is done, months from now.

So I decide to see how Merrill's experience compares with the experiences of people who definitely took ketamine for depression.

I talk to Carlos Zarate, who does ketamine research at the NIH and has never met Merrill. Zarate says patients typically say, " 'I feel that something's lifted or feel that I've never been depressed in my life. I feel I can work. I feel I can contribute to society.' And it was a different experience from feeling high. This was feeling that something has been removed."

I compare this to what Merrill said about her experience: "No more fogginess. No more heaviness. I feel like I'm a clean slate right now. I want to go home and see friends or, you know, go to the grocery store and cook the family dinner."

The similarities are hard to ignore.

And researchers say the consistent patient reactions have actually made it more difficult to do good studies of ketamine. The drug's effects are so powerful and distinctive, they say, it's hard to prevent doctors and patients in an experiment from figuring out who got the drug and who didn't.

* * * * * * *

Sidebar: How Ketamine Works To Treat Depression

Traditional antidepressants like Prozac work on a group of chemical messengers in the brain called the serotonin system. Researchers once thought that a lack of serotonin was the cause of depression, and that these drugs worked simply by boosting serotonin levels.

Recent research suggests a more complicated explanation. Serotonin drugs work by stimulating the birth of new neurons, which eventually form new connections in the brain. But creating new neurons takes time — a few weeks, at least — which is thought to explain the delay in responding to antidepressant medications.

Ketamine, in contrast, activates a different chemical system in the brain – the glutamate system. Researcher Ron Duman at Yale thinks ketamine rapidly increases the communication among existing neurons by creating new connections. This is a quicker process than waiting for new neurons to form and accomplishes the same goal of enhancing brain circuit activity.

To study how ketamine might work, Duman turned to rats. The first image below shows the neuron of a rat that has received no ketamine treatment. The small bumps and spots on the side of the neuron are budding connections between neurons.

A rat neuron without ketamine treatment.
Ronald Duman/Yale University
 
Just hours after giving the rats doses of ketamine, Duman saw a dramatic increase in the number of new connections between brain cells. This increase in neuronal connectivity is thought to relieve depression.

A rat neuron after treatment with ketamine.
Ronald Duman/Yale University
— Andrew Prince

Documentary - Joy Division



Joy Division, whose singer and songwriter, Ian Curtis, suicided before they ever played a gig in the U.S., was one of the most influential punk/post-punk bands of the late 1970s. Like many talented people who die young, Curtis has become a cult icon. Joy Division influenced bands like The Cure and U2, who were contemporaries, as well Bauhaus and other "goth" bands, and even the post-punk revival bands Interpol, Bloc Party, and Editors. 

As a young, disaffected punk kid, the sense of doom and bleakness in their music spoke to the suburban angst I felt. Something about their music feels claustrophobic to me - my peers, who were less miserable apparently, described it as "music to slit your wrists to." There's a "dark night of the soul" feel to their lyrics and music, maybe owing to Curtis' depression.

Joy Division
Great documentary on the revolutionary British punk group Joy Division, and about lead singer Ian Curtis, whom committed suicide before the peak of their popularity. Joy Division later went on to become the popular new wave group New Order.





Here is a recording of a live show, including the sound check songs. No video, but it's a good clean recording.





Set List:

Soundcheck:
01. Heart And Soul 0:00
02. Incubation 5:10
03. Komakino 8:23
04. Isolation (Instrumental) 12:53
05. Isolation 15:37

Gig:
06. Incubation 18:38
07. Wilderness 22:12
08. Twenty Four Hours 25:15
09. The Eternal 29:50
10. Heart And Soul 36:21
11. Love Will Tear Us Apart 41:17
12. Isolation 44:34
13. Komakino 47:57
14. She's Lost Control 52:24
15. These Days 57:44
16. Atrocity Exhibition 1:01:55

PLoS Biology Podcast Episode 01 : Ramachandran, synesthesia, and phantom limbs

The first episode of the PLoS Podcast featured an interview with VS Ramachandran, Director of the Center for Brain and Cognition at the University of California San Diego.  Ramachandran is author of several books, including “Phantoms in the Brain” and “The Tell-Tale Brain.” His lab works on a variety of neurological conditions, including phantom limbs and synesthesia.

PLoS Biology Podcast Episode 01 : Ramachandran, synesthesia, and phantom limbs



Welcome to the PLoS Podcast.  For the first episode,  PLoS Biology Editor Ruchir Shah interviews VS Ramachandran, who is the Director of the Center for Brain and Cognition at the University of California San Diego.  Dr.  Ramachandran has written a number of books, including “Phantoms in the Brain” and “The Tell-Tale Brain”,  about many of the neurological conditions his lab has been studying,  which include phantom limbs and synesthesia.

Along with his graduate student David Brang,  Dr.  Ramachandran has written a new article for PLoS Biology called "Survival of the Synesthesia Gene: Why do people hear colors and taste words."

During the interview,  Dr.  Ramachandran (or “Rama”) and David Brang discuss the potential neural basis of some common and rare forms of synesthesia,  and why this strange condition might have survived evolution.  They then discuss their exploration of some other (rather bizarre) neurological conditions,  and they finish by contemplating how their research into synesthesia might fit into the larger context of the history of science.  Enjoy!

(You can listen here by clicking the Play button,  or to download,  you can visit the Soundcloud page by clicking the link below)




PLoS Biology Podcast Episode 01 – VS Ramachandran by Public Library of Science

Sunday, January 29, 2012

Documentary - Unmistaken Child (2008)

This is an interesting documentary on the Tibetan Buddhist traditions around reincarnation. Depending on one's beliefs, it's possible to either see this as superstition or as enlightened understanding of trans-rational processes.
Unmistaken Child

Unmistaken ChildThe Buddhist concept of reincarnation, while both mysterious and enchanting, is hard for most westerners to grasp.

Unmistaken Child follows the 4-year search for the reincarnation of Lama Konchog, a world-renowned Tibetan master who passed away in 2001 at age 84.

The Dalai Lama charges the deceased monk’s devoted disciple, Tenzin Zopa (who had been in his service since the age of seven), to search for his master’s reincarnation.

Tenzin sets off on this unforgettable quest on foot, mule and even helicopter, through breathtaking landscapes and remote traditional Tibetan villages.

Along the way Tenzin listens to stories about young children with special characteristics, and performs rarely seen ritualistic tests designed to determine the likelihood of reincarnation. He eventually presents the child he believes to be his reincarnated master to the Dalai Lama so that he can make the final decision.

Stunningly shot, Unmistaken Child is a beguiling, surprising, touching, even humorous experience.

Watch the full documentary now. Buy the DVD at Amazon.com.

Robert Stolorow - Dynamic, Dyadic, Intersubjective Systems: An Evolving Paradigm for Psychoanalysis

As an adjunct to my "academic" training as a counselor, I have been participating in a psychoanalytic study group (5 semesters, 10 weeks each). We have completed three semesters so far, and I can honestly say that everything I thought I knew about psychoanalytic therapy was partial at best, and most often just completely wrong.

Coming into this, I knew that attachment theory had reframed a lot of thinking for people like Daniel Siegel and Allan Schore, both of whom were trained in the psychoanalytic tradition (which seems true of many psychiatrists), and both of whom have shifted their studies to affective neurobiology.

While those people worked with the more objective realm of attachment and neuroscience, many other people had been influenced by the profound shift initiated by Heinz Kohut's Self Psychology model, which redirected psychoanalytic thinking from Freudian drive theory to Kohut's self theory.

Foundational to Kohut's model was the idea that infants have various attachment needs that are experienced as "selfobject needs." This is a crucial idea to modern psychoanalytic thinking, so here is a defintion from Wikipedia:
Selfobjects are external objects that function as part of the "self machinery" - 'i.e., objects which are not experienced as separate and independent from the self.'[13] They are persons, objects or activities that "complete" the self, and which are necessary for normal functioning. 'Kohut describes early interactions between the infant and his caretakers as involving the infant's "self" and the infant's "selfobjects"'.[6]

Observing the patient's selfobject connections is a fundamental part of self-psychology. For instance, a person's particular habits, choice of education and work, taste in life partners, may fill a selfobject-function for that particular individual.

Selfobjects are addressed throughout Kohut's theory, and include everything from the transference phenomenon in therapy, relatives, and items (for instance Linus van Pelt's security blanket): they 'thus cover the phenomena which were described by Winnicott[14] as transitional objects. Among 'the great variety of selfobject relations that support the cohesion, vigor, and harmony of the adult self...[are] cultural selfobjects (the writers, artists, and political leaders of the group - the nation, for example - to which a person feels he belongs).'[15]

If psychopathology is explained as an "incomplete" or "defect" self, then the self-objects might be described as a self-prescribed "cure".

As described by Kohut, the selfobject-function (i.e. what the selfobject does for the self) is taken for granted and seems to take place in a "blindzone." The function thus usually does not become "visible" until the relation with the selfobject is somehow broken.

When a relationship is established with a new selfobject, the relationship connection can "lock in place" quite powerfully, and the pull of the connection may affect both self and selfobject. Powerful transference, for instance, is an example of this phenomenon.
Kohut initially identified three major selfobject needs that, when not met developmentally, become forms of transference in therapy - mirroring (having our feelings validated through an other reflecting them back to us), twinship (the sense that you are like me and that I am not alone), and idealization (the need to see a caregiver or other as ideal and to model our own sense of self on that person). Modern Self Psychologists have added several other needs, but these three remain the core.

One other idea is also crucial - Kohut saw the therapeutic relationship as based entirely on the therapist's ability to experience empathy for the client - if we cannot get inside their experience, we cannot understand where their development has been derailed and what is needed to get it moving again. For Kohut, empathy was as much an exploratory tool as it was an experience. Again, from Wikipedia:
Kohut maintained that parents' failures to empathize with their children and the responses of their children to these failures were 'at the root of almost all psychopathology.' [9] For Kohut, the loss of the other and the other's selfobject function (see below) leaves the individual apathetic, lethargic, empty of the feeling of life, without vitality, in short, depressed. [10]

For the infant to move from grandiose to cohesive self and beyond, meant a slow process of disillusionment with phantasies of omnipotence, mediated by the parents: 'This process of gradual and titrated disenchantment requires that the infant's caretakers be empathetically attuned to the infant's needs'.[6]

Correspondingly, to deal in therapy with earlier failures in the disenchantment process, Kohut 'highlights empathy as the tool par excellence, which allows the creation of a relationship between patient and analyst that can offer some hope of mitigating early self pathology.'[11]

Kohut describes human empathy as a therapeutic skill. When a patient acts in a certain way, "put yourself in his/her shoes" - and find out how it feels for the patient to act in this manner.

Using the skill of empathy, the therapist is able to reach conclusions sooner (with less dialogue and interpretation), and there is also a stronger bond between patient and therapist, making the patient feel more fundamentally understood. For Kohut, the implicit bond of empathy itself has a curative effect; but he also warned that 'the psychoanalyst...must also be able to relinquish the empathic attitude' to maintain intellectual integrity, and that 'empathy, especially when it is surrounded by an attitude of wanting to cure directly...may rest on the therapist's unresolved omnipotence fantasies.'[12]

The conceptual introduction of empathy was not intended to be a "discovery." Empathic moments in psychology existed long before Kohut. Instead, Kohut posited that empathy in psychology should be acknowledged as a powerful therapeutic tool, extending beyond "hunches" and vague "assumptions," and enabling empathy to be described, taught, and used more actively.
Kohut was not the first to identify the importance of empathy in therapy, but he was the most important in shifting psychoanalysis from the Freudian objective stance to the emerging intersubjective stance.

In the late 1970s and early 1980s, as Kohut was finally becoming better known in the psychoanalytic world, Robert Stolorow, Donna Orange, George Atwood, Lewis Aron, Bernard Brandchaft, Daniel Stern (mostly in the developmental realm of infants), and Stephen A Mitchell, among many others, were developing an intersubjective model of therapy that owes a debt to Kohut's empathic model, but also to the emerging postmodern models of relational experience.

The paper I am sharing here (only the beginning, as it is too long) is by Stolorow, from 1997, but it offers a good introduction to the ideas of dynamic intersubjective systems theory as it is applied to psychoanalytic work.

Citation:
Robert Stolorow, R. (1997). Dynamic, Dyadic, Intersubjective Systems: An Evolving Paradigm for Psychoanalysis. PSYCHOANALYTIC PSYCHOLOGY, 14(3), 337-346.

An Evolving Paradigm for Psychoanalysis
Robert D. Stolorow, PhD
Institute of Contemporary Psychoanalysis, Los Angeles

Abstract:
Dynamic systems theory is a source of powerful new metaphors for psychoanalysis. Phenomena such as conflict, transference, resistance, and the unconscious itself are grasped from this perspective as dynamically emergent properties of self-organizing, nonlinear, dyadic, intersubjective systems. The conception of development as evolving and dissolving attractor states of intersubjective systems richly illuminates the processes of pattern formation and change in psychoanalysis. Effective interpretations are seen as perturbations of the therapeutic system that permit new organizing principles to come into being.
A new scientific paradigm has been evolving from the investigation of phenomena that have variously been called dynamic, nonlinear, self-organizing, or chaotic systems. With origins in physics, chemistry, and mathematics, this new perspective has been applied to the study of complex biological systems (von Bertalanffy, 1968; Waddington, 1977) and is being employed in the search for common principles underlying the behavior of such diverse phenomena as chemical reactions, clouds, forests, and developing embryos and children. Dynamic systems theory (Thelen & Smith, 1994) is centrally concerned with conceptualizing the process of developmental change—that is, the generation of "emergent order and complexity: how structure and patterns arise from the cooperation of many individual parts" (p. xiii). In accounting for the "messy, fluid, context-sensitive" (p. xvi) nature of the developmental process, this framework is exceptionally well suited to serve as a source of guiding metaphors for psychoanalysis.

In this article I present an overview of some basic tenets of dynamic systems theory, drawing heavily from the work of developmentalists Thelen and Smith (1994). Interspersed throughout the discussion are examples of how systems theory has already infiltrated my thinking about fundamental psychoanalytic issues. I conclude by applying the principles of dynamic systems to a conceptualization of the process of change and resistance to change in psychoanalysis.

Within a general systems philosophy (Laszlo, 1972; Sucharov, 1994), any living system is part of a hierarchy. Each system contains subsystems, or elements, that constitute the whole. Two or more systems interacting cooperatively form a suprasystem. Conceptualizations of psychological development that focus on the child's mental activity as the system under study (e.g., Thelen & Smith, 1994) highlight the exquisitely context-dependent nature of the child's self-regulatory processes as these influence and are influenced by exchanges with caregivers. Other formulations (e.g., Sander, 1985) enter the living hierarchy at the more encompassing level of the child-caregiver suprasystem and emphasize the ongoing processes of reciprocal mutual regulation within the dyad. Self-regulation and mutual regulation always occur simultaneously and are inextricably interrelated (Beebe & Lachmann, 1994). One or another will predominate as a function of the level of the living hierarchy targeted by the investigator. Because psychoanalytic investigation is concerned with comprehending the process of change within the patient—analyst relationship, the level of the hierarchy most relevant to psychoanalysis is the dyadic system. Furthermore, because the focus of psychoanalytic investigation is always psychic, or subjective, reality—the particular dyadic systems formed by the reciprocal interplay between worlds of experience (i.e., intersubjective systems) constitute the unique domain of inquiry of psychoanalysis. Therefore, I have chosen the phrase dynamic, dyadic, intersubjective systems to capture the nature of a new, evolving paradigm for psychoanalysis.

To summarize, I am concerned here with systems concepts existing at three levels of abstraction and generality. The most general and inclusive is the overarching concept of dynamic systems, and the application of principles of dynamic systems to psychoanalysis is the central aim of this article. A specific category of dynamic systems comprises systems formed by the interaction between two human beings (dyadic systems). More specific still are those formed by the interplay between two subjective worlds (intersubjective systems), the unique domain of psychoanalytic inquiry. The concept of a dynamic, dyadic, intersubjective system mends the long-standing false dichotomy in psychoanalysis between intrapsychic and interpersonal theorizing because it brings to focus both the individual's world of inner experience and the embeddedness of this world with other such worlds in a continual flow of reciprocal mutual influence (Stolorow & Atwood, 1992, p. 18). From a dynamic systems perspective, the very distinction between one- and two-person psychologies is obsolete because the individual and his or her intrapsychic world are included as a subsystem within the more encompassing intersubjective suprasystem. For this reason, I have sometimes quipped that perhaps my theoretical viewpoint is a "no-person psychology," concerned as it is with how worlds of inner experience and intersubjective fields mutually constitute one another.

A cardinal feature of the dynamic systems approach to development is that it categorically rejects teleological conceptions of preordained end-states toward which developmental trajectories are presumed to aim. Accordingly,
development does not "know" where it is going from the start.... There is no end-state other than the end of life itself.... Development is the outcome of the self-organizing processes of continuously active living systems [italics added]. (Thelen & Smith, 1994, p. 44)
Also rejected is the idea, prominent in much psychoanalytic developmental theory,
that development unfolds according to some predetermined schema or epigenetic
master plan:
Although behavior and development appear structured, there are no structures. Although behavior and development appeal' rule-driven, there are no rules. There is complexity. There is a multiple, parallel, and continuously dynamic interplay of perception and action, and a system that, by its thermodynamic nature, seeks certain stable solutions. These solutions emerge from relations, not from design. When the elements of such complex systems cooperate, they give rise to behavior with a unitary character, and thus (:o the illusion of structure. But the order is always executory, rather than rule-driven, allowing for the enormous sensitivity and flexibility of behavior to organize and regroup around task and context. ... [Such organization is] emergent and not designed [italics added], (Thelen & Smith, 1994, p. xix)
Rejection of teleological thinking and of the notion of preestablished developmental programs has been a hallmark of what has come to be known as the intersubjective perspective in psychoanalysis (Stolorow, Atwood, & Brandchaft, 1994). Psychoanalytic inteirsubjectivity theory is a field theory or systems theory that seeks to comprehend psychological phenomena not as products of isolated intrapsychic mechanisms and fixed intrapsychic structures, but as forming at the interface of reciprocally interacting worlds of experience (Stolorow & Atwood, 1992). From this perspective, intrapsychic determinism gives way to an unremitting contextualism for which "a dynamic [systems] account provides a biological rationale" (Thelen & Smith, 1994, p. xxi). With regard to psychological development, my collaborators and I, along with Sander (1985) and Beebe and Lachmann (1988), proposed that the organization of the child's experience must be seen as a property of the child-caregiver system of mutual regulation and, further, that it is the recurring patterns of intersubjective transaction within the developmental system that result in the establishment of invariant principles and themes that unconsciously organize the child's subsequent experiences. The forging of such principles and themes within the child-caregiver system is an example of dynamically emergent form, of "pattern formation without a program" (Thelen & Smith, 1994, p. 71). In this view of psychological development, we, like Stern (1985), eschew traditional psychoanalytic assumptions about universally occurring developmental phases dominated by innately preprogrammed imagery and crises. Contrary to Kohut's (1984) idea that a self possesses an inherent design awaiting a responsive milieu that will enable it to unfold, it is our view that the trajectory of self-experience is shaped at every point in development by the intersubjective matrix in which it crystallizes (Stolorow & Atwood, 1992). In harmony with the dynamic tenet that "all mental activity is emergent, situated, [and] historical" (Thelen & Smith, 1994, p. xxiii), we hold that any psychological constellation can be grasped only in terms of its unique intersubjective history, the relational systems in which it originated and is continuing to be maintained.
Read the whole essay.