Thursday, October 23, 2008

Treating Post Traumatic Stress Disorder

Neuroscientists have been looking for a way to short-circuit the progression of traumatic events into PTSD. While we are beginning to understand the mechanisms at work, we haven't yet figured out how to disrupt the system. Until now. Maybe. In some situations.

Cortisol is a stress hormone, released when we are under various forms of stress, both physical and psychological. Much of the time, cortisol is a hormone we want to limit as much as possible, since one of its actions is to increase muscle wasting and blood glucose levels (fight, flight, or freeze response). But when trauma occurs, more cortisol might be exactly what the brain needs to prevent PTSD from developing.

High-Dose Hormone Treatment Might Reduce Risk For Post Traumatic Stress Disorder (PTSD)

ScienceDaily (Oct. 22, 2008) — Cortisol helps our bodies cope with stress, but what about its effects on the brain? A new study by Cohen and colleagues, appearing in the October 15th issue of Biological Psychiatry, suggests that the answer to this question is complex. In an animal model of posttraumatic stress disorder (PTSD), high doses of a cortisol-related substance, corticosterone, prevented negative consequences of stress exposure, including increased startle response and behavioral freezing when exposed to reminders of the stress.

However, low-dose corticosterone potentiated these responses. This finding suggests that corticosterone levels may influence both vulnerability and resilience in a dose-dependent manner through its involvement in memory processes.

One of the complexities in understanding PTSD is the context-dependency of adaptation. In some situations, for example following a car accident in an otherwise secure community, one objective of treatment is to restore a sense of normalcy and control of one’s life. Within this context, the high-dose corticosterone would seem to be the indicated treatment. However, one could imagine scenarios where hypervigilance and heightened emotional reactivity could be adaptive, perhaps in a combat zone. In that case, the lower and more typical corticosterone levels might help soldiers adapt to the continuing risks of combat.

But, people do not spend their lives in a single context. “In the case of helping soldiers adjust to the stress of war, we have to think both short-term and long-term, to help soldiers adjust to combat, but also to help them return from combat to resume peacetime life. Thus, we need further guidance from animal research about how to help soldiers adjust flexibly across contexts, from the battlefield to the breakfast table,” as explained by John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System.

Corresponding author Dr. Hagit Cohen concludes that, “single high-dose corticosteroid treatment may thus be worthy of clinical investigation as a possible avenue for early pharmacotherapeutic intervention in the acute phase, aimed at prevention of chronic stress-related disorders, such as PTSD. In this sense, it brings treatment of PTSD to a new era – an era of secondary prevention.”

Adapted from materials provided by Elsevier, via AlphaGalileo.

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